| 1823 |
On December 20th, the SC General Assembly granted the request of the Medical Society of South Carolina for a charter to establish a Medical College in Charleston |
| 1824 |
Medical College of South Carolina opened |
| 1825 |
First graduating class with five graduates (Eli Geddings, first graduate) |
| 1832 |
School split into the Medical College of South Carolina and the Medical College of the State of South Carolina |
| 1839 |
The two schools merged under the name Medical College of the State of South Carolina |
| 1847 |
James Moultrie, Jr., M.D. (Dean, School of Medicine) is instrumental in founding of the American Medical Association |
| 1852-1853 |
Louis Agassiz, naturalist, served on the faculty of the School of Medicine |
| 1860-1865 |
Julian John Chisolm invented a new chloroform inhaler, which bears his name |
| 1861 |
College closed after the March graduation due to the Civil War |
| 1861 |
Julian John Chisolm (Dean, 1866-67) published his A Manual of Military Surgery |
| 1863 |
Francis Peyre Porcher (Faculty, School of Medicine), published his Resources of the Southern Fields and Forests |
| 1865 |
College reopened when the faculty returns from the Civil War |
| 1881 |
Pharmacy Department of the MCSC is chartered |
| 1890 |
Three-year graded course established for the College of Medicine |
| 1894 |
Medical College opened to women |
| 1898 |
First woman admitted to the College of Medicine |
| 1899 |
A four-year graded course established for the College of Medicine |
| 1901 |
First women graduated from the College of Medicine: Love Rosa Hirschmann Gantt, Emilie Melanie Viett Rundlett |
| 1913 |
Medical College of the State of South Carolina became a state institution |
| 1914 |
Medical College of the State of South Carolina campus moves to its current location |
| 1936 |
Kenneth Lynch (President, 1949 - 1960) and William Atmar Smith link brown lung disease (asbestosis) with cancer |
| 1947 |
Horace G. Smithy (Assistant Professor of Surgery) designs valvulotome and pioneered mitral valve heart surgery |
| 1948 |
Elsie Taber becomes first female full-time professor in School of Medicine |
| 1952 |
College name changes back to the original Medical College of South Carolina |
| 1965 |
First African-American student admitted to the College of Medicine (did not graduate) |
| 1965 |
Thomas S. Hargest and Curtis P. Artz (Department of Surgery) invent fluidized airbed for use in burn therapy |
| 1970 |
Family Practice Program established as one of the first in the nation. Dr. Hiram B. Curry named Professor and Chairman of the new department |
| 1971 |
First African American graduates from the College of Medicine, Bernard W. Deas, Jr |
| 1973 |
First female African American graduates from the College of Medicine, Delores Gibbs |
| 1974-1982 |
Albert Bruce Sabin (developer of oral polio vaccine) is Distinguished Research Professor of Biomedicine |
| 1997 |
Anesthesiologist Joanne Conroy, M.D., appointed the first woman department head in the history of the College of Medicine |
| 2009 |
Hollings Cancer Center awarded National Cancer Institute designation |
| 2010 |
MUSC hires first female dean of the College of Medicine, Etta Pisano |
